Rabies, a fatal disease of humans and all other mammals, is caused by a virus which has been associated with animal bites for more than 3 000 years and it is the oldest infectious disease known to medical science. Dogs have long been recognised as the main transmitters of the disease to people. When compared with other formidable human diseases such as Bubonic Plague and Smallpox, and animal diseases such as Rinderpest and Anthrax, Rabies has probably never caused comparably high numbers of deaths in humans and animals. However, the horrendous manner in which Rabies manifests itself in its victims continues to attract the attention of scientists, health and veterinary workers. The true scale of Rabies in South Africa remains clouded by the many thousands of people protected by post-exposure treatment each year after Rabies exposure and the undiagnosed human and animal Rabies cases not reflected in official statistics.